Abstract
Menthol and Methyl Salicylate are used in topical treatment and high-dose dermal patch, to relive pain of minor aches and pains of muscle and joints associated with arthritis. Two types of formulations available in the market. In one formulation Menthol and Methyl Salicylate are used as two active ingredients and it is Cream based formulation. In another gel based formulation, only Menthol is added as an active ingredient. Both formulations are used for different therapeutic effects during pain management. The purpose of the present study was to develop accurate and precise single analytical method for determination of Menthol and Methyl Salicylate content in topical cream and gel formulations by gas chromatography. Internal standard technique was used for quantitation of Menthol and Methyl Salicylate by Gas Chromatography in order to reduce sample preparation and injection related errors thereby improving method accuracy. Further developed method was validated to prove its suitability for intended.
Published Version
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