Abstract
A simple, precise and reproducible stability indicating RP-HPLC chromatographic method has been developed and validated for the simultaneous estimation of Emtricitabine and Tenofovir Disoproxil Fumarate used as Anti HIV drugs available in tablet dosage form. The method is based on the measurement of Emtricitabine and Tenofovir Disoproxil Fumarate at 269 nm using C18 Column. Phosphate Buffer pH 5.7: Methanol (85:15) as Mobile phase A and Water: Methanol (15:85) as Mobile Phase B using Gradient method. The results of analysis have been validated stastically and recovery studies confirmed the accuracy of the proposed method. This method was successfully applied to the determination of these drugs in pharmaceutical dosage forms. The proposed chromatographic method assured required Specificity with degradation study, Precision, Linearity, Accuracy and Robustness.
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