Analysis on the level of serum 25-hydroxyvitamin D3 in mild-moderate ulcerative colitis patients

Abstract

Objective To investigate the changes of serum 25-hydroxyvitamin D3[25 (OH) D3] levels in initial mild-moderate ulcerative colitis (UC) patients before and after treatment, and compare with healthy people. Methods Thirty initial mild-moderate UC patients (twenty one mild UC patients, nine moderate UC patients) diagnosed at The First Affiliated Hospital of Medical College, Shihezi University, from September 2017 to June 2018 were prospectively enrolled. The levels of serum 25 (OH) D3 were detected by electrochemiluminescence before treatment and three months after treatment. At the same time, blood samples of twenty five healthy people were collected and detected as control. Results All the patients were clinically relieved after treatment. The levels of serum 25 (OH) D3 in UC patients after treatment were higher compared to treatment [ (34.98±15.09) μg/L vs. (23.59±16.78) μg/L, P<0.001], but before and after treatment the levels were both lower compared to healthy people[before treatment vs. healthy people: (23.59±16.78) μg/L vs. (45.35±15.55) μg/L, P<0.001; after treatment vs. healthy people: (34.98±15.09) μg/L vs. (45.35 ± 15.55) μg/L, P = 0.016) ]. The levels of serum 25 (OH) D3 between mild UC patients and moderate UC patients before or after treatment were not significantly different [mild UC before treatment vs. moderate UC before treatment: (27.01±18.40) μg/L vs. (16.44±9.28) μg/L, P = 0.114; mild UC after treatment vs. moderate UC after treatment: (34.48±14.74) μg/L vs. (36.18±16.79) μg/L, P = 0.786]. Conclusion The serum 25 (OH) D3 levels of mild-moderate UC patients increase at the clinically relief stage, but are still lower than those in healthy people. Key words: Inflammatory bowel disease; Ulcerative colitis; Vitamin D; Degree of disease activity