Abstract

Objective To explore the function of stereotactic radiation therapy (SRT) and whole-brain radiation therapy (WBRT) in treatment of multiple brain metastasis tumor. Methods Fifty-two patients with multiple brain metastasis tumor were retrospectively analyzed. The patients were divided into simple stereotactic radiation therapy group (22 cases) and whole-brain radiation therapy + stereotactic radiation therapy group (30 cases) according to the radiation therapy method. The median overall survival time and distant brain tumor recurrence rate in 1 year etc. were compared between 2 groups. Results There were no statistical differences in the median overall survival time and fatality rate between simple stereotactic radiation therapy group and whole-brain radiation therapy + stereotactic radiation therapy group: 13.0 months (95% CI 8.05-27.84) vs. 13.4 months (95% CI 8.57-19.48), 86.36% (19/22) vs. 86.67% (26/30), P>0.05. The distant brain tumor recurrence rate in 1 year in simple stereotactic radiation therapy group was significantly higher than that in whole-brain radiation therapy + stereotactic radiation therapy group: 45.45% (10/22) vs. 20.00% (6/30), and there was statistical difference (χ2=3.861, P=0.049). Conclusion Stereotactic radiation therapy and whole-brain radiotherapy can achieved similar median overall survival time. Key words: Neoplasm metastasis; Radiosurgery; Radiotherapy, computer-assisted; Survival time

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