Analysis on the correlation of plasma D-dimer level with chronic obstructive pulmonary disease

Abstract

Objective To investigate the correlation between the D-dimer level and the acute exacerbation of chronic obstructive pulmonary disease(AECOPD). Methods The changes of D-dimer levels in 156 patients(AECOPD group) before and after treatment were measured and compared with the D-dimer levels of 156 healthy subjects(control group). Results The concentration of plasma D-dimer in the AECOPD group was (1.35±1.46)mg/L, which was significantly higher than (0.25±0.16)mg/L in the control group, and the difference was statistically significant(t=9.354, P<0.05). The level of plasma D-dimer in the AECOPD group was (0.69±0.87)mg/L, and compared with (1.35±1.46)mg/L before treatment, the difference was statistically significant(t=4.850, P<0.05). Conclusion D-dimer level is correlated to the condition of patients with chronic obstructive pulmonary disease, it can be used as one of the indicators to diagnose whether a patient is in hypercoagulable state or suffers thrombotic diseases. Key words: D-dimer; Pulmonary disease, chronic obstructive