Abstract

In clinical chemistry extensive gas phase investigations (GLC and GC-MS) of urinary steroids should be considered as comprehensive analyses carried out on metabolic families of compounds. Such a procedure must cope with their physiopathological consistency. First, such assays apply to urine specimens of extreme diversity due to age, sex, pregnancy and clinical status etc…. Therefore, the selection of metabolic groups of steroids should give a clear cut clinical significance. Second, in order to develop these assessments to a useful purpose they should not only compare with results obtained by more conventional methods but also be explicit and complete them.

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