Abstract
BackgroundMast cells are most widely acknowledged as a centralmediator of allergic reactions. Recent literature has alsoimplicated mast cells in a variety of biological andpathological conditions, spurring an interest in thegenetic regulation of mast cell function and develop-ment. In a survey of global gene expression, we identi-fied higher Tie2 mRNA expression in bone marrowderived mast cells (BMMC) in relation to a Lin
Highlights
Mast cells are most widely acknowledged as a central mediator of allergic reactions
In a survey of global gene expression, we identified higher Tie2 mRNA expression in bone marrow derived mast cells (BMMC) in relation to a Lin-Sca1 +cKit+ (LSK) bone marrow population
Our objective is to explore the function of Tie2 in mast cell development and biology
Summary
Mast cells are most widely acknowledged as a central mediator of allergic reactions. Recent literature has implicated mast cells in a variety of biological and pathological conditions, spurring an interest in the genetic regulation of mast cell function and development. In a survey of global gene expression, we identified higher Tie mRNA expression in bone marrow derived mast cells (BMMC) in relation to a Lin-Sca1 +cKit+ (LSK) bone marrow population. Tie (gene name Tek) is a receptor tyrosine kinase more commonly known for its expression on endothelial cells and a receptor for angiopoietins including Ang and 2. Our objective is to explore the function of Tie in mast cell development and biology
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