Abstract
Objective To investigate the correlation between the positive combinations of different items in antinuclear antibody speckled pattern in serum and those in specific antinuclear antibody profile.Methods Contrast analysis was carried out to detect the type of anti-ANA profile(including antibodies to U1-Nrnp,Sm,SS-A,SS-B,Scl-70,Jo-l,SCL-70,PM-Scl,centromere B,nukleosome,PCNA,ds-DNA,histones,ribosomal-P protein and AMA-M2)of 87 cases with positive speckled antinuclear antibodies.Results There were 23 types of positive combinations of different items in the ANA profile of speckled antinuelear antibody.And 13 types of the specific antinuclear antibodies were positive,except SCL-70 and PM-Scl.The positive rates of single antibodies and their comhinations (including histone with negative ds-DNA,Sm,nukleosome,PCNA,Rib-P.P)could reach as high as 19.5%(17/87).The sensitivity of diagnosis for systemic lupus erythematosus(SLE)would be increased through examining these antibodies together.There was no significant association between the positive rates of the ANA profile and the titer of antinuclear antibody.Conclusion The specific type of anti-ANAs antibodies cannot be predicated simply according to the fluorimetrie caryotypo.Combined examination of multiple approaches can increase the sensitivity and specificity of diagnosis for SLE.Specific antinuclear antibody profile should be,analyzed in the patients with low titer of speckled antinuclear antibodies. Key words: Antinuclear antibody; Speckled pattern; Antinuclear antibody profile; Titer
Published Version
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