Abstract
The aim of the present study was to investigate the association between periodontitis and chronic gastritis/peptic ulcer using a cross-sectional study design. The present prospective cohort study used epidemiological data from the Korean Genome and Epidemiology Study (KoGES) recorded from 2004 to 2016. Among 173,209 participants, 9983 with periodontitis and 125,336 with no periodontitis were selected. Histories of chronic gastritis and peptic ulcer between periodontitis and no periodontitis participants were analyzed. The participants were questioned around any history of hypertension, diabetes mellitus, hyperlipidemia, cerebral stroke, ischemic heart disease, periodontitis, body mass index, smoking, alcohol consumption, nutritional intake, and financial income. Chi-square tests, independent t-tests, two-tailed analyses were used in statistical analysis of the data. The adjusted odds ratio of chronic gastritis was 2.22 (95% confidence interval [CI] = 2.10–2.34, p < 0.001) and that of peptic ulcer was 1.86 (95% CI = 1.74–1.98, p < 0.001) in model 2. This study demonstrated that periodontitis was associated with an increased risk of chronic gastritis/peptic ulcer. These findings provide additional evidence for an association between periodontitis and chronic gastritis/peptic ulcer.
Highlights
Chronic gastritis and peptic ulcer are acid-induced diseases that affect the stomach and proximal duodenum
The aim of this study was to investigate the association between periodontitis and chronic gastritis/peptic ulcer using a cross-sectional study design and the KoGES HEXA (Korean Genome and Epidemiology Study Health Examinee) data
This study demonstrated a significant association between periodontitis and chronic gastritis/peptic ulcer in all ages and sex groups when using the
Summary
Chronic gastritis and peptic ulcer are acid-induced diseases that affect the stomach and proximal duodenum. These diseases are identified by denuded mucosa, and confirmed histologically by extension into the submucosa or muscularis propria [1]. An excessively acidic environment in combination with dietary or stress factors have been considered to induce chronic gastritis/peptic ulcer. The discovery of H. pylori (Helicobacter pylori) infection and the use of non-steroidal anti-inflammatory drugs (NSAIDs) have changed previous perceptions [2]. Res. Public Health 2020, 17, 4387; doi:10.3390/ijerph17124387 www.mdpi.com/journal/ijerph
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