Abstract
A high degree of IS 6110 restriction fragment length polymorphism (RFLP) is observed amongst the different strains of the Mycobacterium tuberculosis complex. The sequences of the IS 6110 flanking regions from a M. tuberculosis strain harbouring four IS 6110 copies were determined. Duplication of 3–4 nucleotides was found at the extremities of the four IS 6110 copies, suggesting that IS 6110 RFLP is due to transposition of the IS element. One of the copies of IS 6110 analysed in the study was shown to be located at the same site in the genome of M. tuberculosis as the single copy present in an M. bovis BCG strain.
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