Abstract
Impaired bone metabolism in cancer patients may be manifested by the development of osteoporosis, the appearance of pathological fractures, and the development of metastatic bone involvement. Given the need to prescribe chemotherapy for the treatment of cancer, bone regeneration is quite often the case with the use of anticancer chemotherapy.Conclusions. Cancer patients are at high risk for osteoporosis and bone fractures due to the direct effects of the tumor itself and the side effects of chemotherapy. The use of antitumor chemotherapy affects the rate of bone remodeling, in particular inhibits the function of osteoblasts, reduces their number, stimulates osteoclasts and disrupts the processes of bone mineralization. As a result, there is a decrease in bone mass, which significantly increases the risk of fractures in cancer patients during chemotherapy.
Highlights
Impaired bone metabolism in cancer patients may be manifested by the development of osteoporosis, the appearance of pathological fractures, and the development of metastatic bone involvement
Cancer patients are at high risk for osteoporosis and bone fractures due to the direct effects of the tumor itself and the side effects of chemotherapy
The use of antitumor chemotherapy affects the rate of bone remodeling, in particular inhibits the function of osteoblasts, reduces their number, stimulates osteoclasts and disrupts the processes of bone mineralization
Summary
Враховуючи необхідність призначення хіміотерапії для лікування злоякісних новоутворень, регенерація кісткової тканини досить часто відбувається за умов застосування протипухлинних хіміопрепаратів. Мета роботи — проаналізувати зміни кісткової системи при онкологічних захворюваннях та з’ясувати вплив хіміотерапії на регенерацію кісток. Застосування протипухлинної хіміотерапії впливає на темпи ремоделювання кісткової тканини, зокрема пригнічує функцію остеобластів, зменшує їх кількість, стимулює остеокласти і порушує процеси мінералізації кісткової тканини.
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