Abstract
BackgroundThe Health Product Profile Directory (HPPD) is an online database describing 8–10 key characteristics (such as target population, measures of efficacy and dosage) of product profiles for medicines, vaccines, diagnostics and other products that are intended to be accessed by populations in low- and middle-income countries. The HPPD was developed by TDR on behalf of WHO and launched on 15 May 2019.MethodsThe contents of the HPPD were downloaded into an Excel™ spreadsheet via the open access interface and analysed to identify the number of health product profiles by type, disease, year of publication, status, author organization and safety information.ResultsThe HPPD contains summaries of 215 health product profiles published between 2008 and May 2019, 117 (54%) of which provide a hyperlink to the detailed publication from which the summary was extracted, and the remaining 98 provide an email contact for further information. A total of 55 target disease or health conditions are covered, with 210 profiles describing a product with an infectious disease as the target. Only 5 product profiles in the HPPD describe a product for a non-communicable disease. Four diseases account for 40% of product profiles in the HPPD; these are tuberculosis (33 profiles, 15%), malaria (31 profiles, 14%), HIV (13 profiles, 6%) and Chagas (10 profiles, 5%).ConclusionThe HPPD provides a new tool to inform priority-setting in global health — it includes all product profiles authored by WHO (n = 51). There is a need to standardise nomenclature to more clearly distinguish between strategic publications (describing research and development (R&D) priorities or preferred characteristics) compared to target product profiles to guide a specific candidate product undergoing R&D. It is recommended that all profiles published in the HPPD define more clearly what affordability means in the context where the product is intended to be used and all profiles should include a statement of safety. Combining the analysis from HPPD to a mapping of funds available for R&D and those products in the R&D pipeline would create a better overview of global health priorities and how they are supported. Such analysis and increased transparency should take us a step closer to measuring and improving coordination of efforts in global health R&D.
Highlights
The Health Product Profile Directory (HPPD) is an online database describing 8–10 key characteristics of product profiles for medicines, vaccines, diagnostics and other products that are intended to be accessed by populations in low- and middle-income countries
In this paper, we analyse the content of the new Health Product Profile Directory (HPPD) developed by TDR and assess the potential of HPPD as a new tool to inform product priority-setting for global health
The HPPD has specific criteria to include only those product profiles that describe health products intended to be accessed by populations in low- and middle-income countries where conventional research and development (R&D) market incentives do not function for diseases sometimes described as neglected diseases
Summary
The Health Product Profile Directory (HPPD) is an online database describing 8–10 key characteristics (such as target population, measures of efficacy and dosage) of product profiles for medicines, vaccines, diagnostics and other products that are intended to be accessed by populations in low- and middle-income countries. The HPPD is a searchable database describing 8– 10 key characteristics (such as target population, measures of efficacy and dosage) of profiles for medicines, vaccines, diagnostics and other products. The HPPD has specific criteria to include only those product profiles that describe health products intended to be accessed by populations in low- and middle-income countries where conventional research and development (R&D) market incentives do not function for diseases sometimes described as neglected diseases. TPPs have primarily been used by regulatory bodies and the pharmaceutical industry since approximately 2005 [2], we see this term used in the not-for-profit space, for example, by the Product Development Partnerships (PDP) [3]
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