Analysis of the factors associated with the long-term curative effect and prognosis of primary vaginal carcinoma

Abstract

Objective: To investigate the clinical factors that affect the prognosis of patients with primary vaginal cancer. Methods: Clinical data of 118 primary vaginal cancer patients with pathological diagnosis and clinical follow-up data from the Department of Gynecology of Liaoning Cancer Hospital & Institute from 1999 to 2014 were collected and retrospectively analyzed. The relationship of prognosis and factors including age, history of hysterectomy, pathological types, International Federation of Gynecology and Obstetrics (FIGO) stage, tumor size, tumor location and therapeutic methods were analyzed, respectively. Results: The median survival time of the 118 patients was 93 months. The survival rates of 1, 3, 5, 10 and 15-year were 89.7%, 68.1%, 60.4%, 37.3% and 19.0%, respectively.The results of univariate analysis showed that the FIGO stage, pathological types, tumor size, therapeutic methods and tumor location were related to the prognosis of patients with primary vaginal cancer (all P<0.05), while the patients' age, history of hysterectomy were not (all P>0.05). The results of Cox multivariate regression analysis indicated that FIGO stage (P=0.008), tumor location (P=0.001) and therapeutic methods (P=0.007) were independent prognostic factors of the patients with primary vaginal cancer. Conclusions: Prognostic factorsofpatients with primary vaginal cancer include FIGO stage, pathological types, tumor size, therapeutic methods and tumor location. Among them, therapeutic methods and tumor location are the independent prognostic factors.