Abstract

Objective To analyse the prognosis of malignant germ cell tumor of ovary(MOGCTs) with different clinicopathological features. Methods The clinical and pathological data of 2 801 patients with MOGCTs in SEER database were analyzed. Survival curve was plotted by Kaplan-Meier method. Univariate analysis was performed by log-rank test. Cox regression model was used for multivariate analysis. Results Univariate analysis showed that the prognosis was associated with the age of diagnosis (χ2=93.119, P=0.000), race (χ2=12.894, P=0.002), pathological types (χ2=316.287, P=0.000), pathological differentiation (χ2=27.476, P=0.000), International Federation of Gynecology and Obstetrics (FIGO) stage (χ2=187.837, P=0.000), tumor location (χ2=36.959, P=0.000), tumor size (χ2=319.981, P=0.000), lymphatic metastasis (χ2=20.849, P=0.000) and scope of operation (χ2=170.370, P=0.000). Multivariate analysis showed that the prognosis was associated with FIGO stage (P=0.004, 95% CI=1.204-2.603), pathological types (P=0.010, 95% CI=1.109-2.144), and the age of diagnosis (P=0.009, 95% CI=1.340-7.584). Conclusion FIGO stage, pathological type and age are independent risk factors for prognosis of MOGCTs. Therefore, it is feasible for young women to perform the operation of preserving reproductive function. Key words: Ovary; Malignant germ cell tumor of ovary (MOGCTs); Prognosis

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