Analysis of the effects of laparoscopic radical gastrectomy for gastric cancer on inflammatory cytokines and intestinal barrier function in patients

Abstract

Objective To study the effects of laparoscopic radical gastrectomy for gastric cancer on serum inflammatory cytokines and intestinal barrier function in patients. Methods Retrospective analysis was used to investigate a total of one hundred and forty gastric cancer patients in Ezhou Central Hospital from January 2014 to September 2016, including 66 cases with laparoscopic radical gastrectomy (laparoscopic group) and 74 cases with traditional open radical gastrectomy (traditional group), the perioperative indexes, inflammatory factors and intestinal barrier function of the two groups were compared. Results In the laparoscopic group, the amount of bleeding loss in the laparoscopic group ( (86.8 ± 15.2) ml), the incision length ( (6.2 ± 1.4) cm), the first anal exhaust time ( (3.0 ± 0.6) d), the fluid diet time ( (4.6 ± 0.9) d), the postoperative hospitalization ( (8.8 ± 1.7) d) were all lower than those in the traditional group ( (158.2±25.0) ml, (16.3±2.7) cm, (3.6±0.7) d, (5.1±0.8) d, (10.3±2.5) d), the differences were statistically significant (P=0.000, 0.000, 0.000, 0.014, 0.001); the operation time of the traditional group was (196.5±27.8) min, the number of lymph nodes was (21.6±2.8), compared with those in the laparoscopic group ( (192.5±30.3) min, (22.0±3.1), P=0.421, 0.137). The levels of WBC, IL-6, CRP, TNF-ɑ, COR, plasma D-lactic acid and diamine oxidase in the laparoscopic group were lower than those in the traditional group (P=0.000). Conclusion The effect of laparoscopic radical gastrectomy on serum inflammatory cytokines and intestinal barrier function in patients is not obvious. Key words: Laparoscopy; Gastric cancer; Inflammatory cytokine; Intestinal barrier function