Analysis of the difference on the effect of atropine sulphate and cyclopentolate hydrochloride in the treatment of youth hyperopia cycloplegic refraction

Abstract

Objective To compare the effect of atropine sulphate and cyclopentolate hydrochloride in the treatment of youth hyperopia cycloplegic refraction,and provide the basis for a reasonable choice of the youth cycloplegic refraction drugs.Methods Ninety hyperopia children met inclusion criteria with refractive errors (180 eyes) were subjected to cycloplegic refratometry by 1％ cyclopentolate hydrochloride followed with 1％ atropine sulphate eye used gel.The refractive results,pupil size,residual adjustment amount and systemic side reactions were measured and compared by TOPCON.Results The coincidence rate of spherical lens degrees,cylinder lens degrees and axis of astigmatism degrees respectively was 84.44％ (152/180),92.78％ (167/180) and 92.78％ (167/180) between atropine sulphate and cyclopentolate hydrochloride.The spherical lens degrees of cyclopentolate hydrochloride was lower than atropine sulphate,the difference was statistically significant (P ＜0.01),the cylinder lens degrees and axis of astigmatism degrees had no significant difference between two drugs (P＞ 0.05).The pupil size and residual adjustment amount of cyclopentolate hydrochloride had no significant difference with atropine sulphate (P ＞ 0.05).The incidence of adverse reactions of cyclopentolate hydrochloride was 3.33％ (3/90),atropine sulphate was 13.33％ (12/90),the cyclopentolate hydrochloride was significantly lower than atropine sulphate (P ＜ 0.05).Conclusion The cyclopentolate hydrochloride has powerful,fast and secure feature in the treatment of youth hyperopia cycloplegic refraction,has good ciliary muscle paralysis effect,has longer paralysis time,as effective as the atropine sulphate,and has a shorter recovery time and better security,is ideal cycloplegic drugs for youth hyperopia cycloplegic refraction. Key words: Atropine; Cyclopentolate; Mydriatics