Analysis of the curative effect of 427 cases of pancreatic cancer

Abstract

Objective To analyze the clinical effects of surgical treatment on 427 cases of pancreatic cancer. Methods A total of 427 patients with pancreatic cancer were selected. According to treatment patterns, the 427 cases of pancreatic cancer were divided into three groups: radical surgery group (including pancreatoduodenectomy and pancreatoduodenectomy combined with splenectomy, n=268); palliative operation (n=122) and no surgery group (n=37). The postoperative complication rate and operative mortality were evaluated in the operative group. The follow-up period was 3 years. The survival rates of the three groups were compared, and the survival rate charts were drawn. The quality of life scores of the three groups were measured, and the difference of the scores between the two groups was compared, and the clinical effects of surgical treatment was evaluated. Results The complication rate was significantly higher in radical surgery group than that in palliative group (P 0.05). The survival rate in the radical resection group was significantly higher than that in the other two groups, and the differences were significant (P 0.05). The survival rates of 1, 2, 3-year in radical surgery group were 52.94%, 31.33%, 11.74%, respectively, which were higher than those in palliative group and no surgery group. There was no significant difference between the palliative group and the no operative group in the 1, 2, 3-year survival rates (P>0.05). The quality of life assessment showed that the score of operation group was higher than that of no operative group, the difference was significant (P<0.05), and the score of radical resection group was higher than that of palliative operation group, the difference was significant (P<0.05). Conclusions Radical resection of pancreatic cancer (including pancreaticoduodenectomy and pancreatic body tail combined with splenectomy) can significantly improve the treatment effect and improve prognosis, improve the long-term survival rate, and significantly improve the quality of life of patients. For the patients who can not be excised radical excision, palliative surgery should be strived, in order to improve the survival rate and improve the quality of life. Key words: Pancreatic adenocarcinoma; Radical surgery; Palliative operation