Analysis of the Correlation Between the Tissue Metabolism of Sodium Alginate Microspheres and the Interventional Therapy of Liver Cancer

Abstract

To explore the tissue metabolism of sodium alginate microspheres in treating liver cancer using alginate microspheres. Rabbit liver cancer model was established by direct inoculation of liver cancer tissues. Rabbits of experimental group were treated with hepatic arterial embolization (HAE) as follows: sodium alginate microspheres was injected through femoral artery to three targeting sites which was 0.5 cm (proximal group), 2 cm (middle group), and 3.5 cm (distal group) far from the lesion, respectively, to block the tumor’s nutrient supply. Short-term clinical efficacy, 3 month survival rate, 6-month mortality rate, 1-year survival rate, and adverse reactions were used as parameters to analyze the prognosis. The complete remission rates of proximal group, middle group, and distal group was 80%, 40%, and 20%, respectively. The complete remission rate of proximal group was significantly higher than other two groups, and the complete remission rate of middle group was significantly higher than distal group (P < 0.05). In terms of progress, a significant difference was observed between proximal group and distal group (P < 0.01). 3-month and 1-year survival rates were increased along with decrease of distance from injection position to the lesion with a correlation equation of y = −15.567x + 104.47 (R2 = 0.9429) and y = −13.333x + 91.133 (R2 =0.9639). Six-month mortality rate decreased along with the decrease of distance from injection position to the lesion with the correlation equation of y = 15.343x−5.9967 (R2 = 0.9943). The prognosis is correlated with the injection position of alginate microspheres. The closer the injection position to the lesion, the better prognosis.