Analysis of the content of mineral elements in connective tissues in patients with bisphosphonate osteonecrosis

Abstract

BACKGROUND: The presence of a large number of pathological studies and a significant amount of literature on high bone density in patients with bisphosphonate osteonecrosis determined the conduct of this study.
 AIM. To monitor micro- and macronutrients in patients with bisphosphonate osteonecrosis of the jaws, to detail their role in the pathological process.
 MATERIALS AND METHODS. In 184 patients with bisphosphonate necrosis, after sequestrectomy, the micro- and macronutrient composition of bone fragments removed from the lesion was analyzed.
 RESULTS. Deviations from reference values were found in such elements as sulfur (S2-), chlorine (Cl-), potassium (K+), calcium (Ca2+), phosphorus (P3+). The dynamics of micro and macro elements correlated with the clinical picture of the pathological process under study and the number of sessions or courses of adjuvant therapy.
 CONCLUSIONS. It is assumed that violations of cascade physiological reactions that develop as a result of violations of the mineral composition in the connective tissue are due to the pharmacokinetic properties of bisphosphonate preparations. The study of a number of micro and macro elements is predetermined by their role in the life and functional activity of amino acids, enzymatic systems, importance in the structure of cells and tissues.
 Keywords
 Bisphosphonate-Associated Osteonecrosis of the Jaw, micro and macro elements, sequestrations, bone fragments.