Analysis of the ability of nano-mixture of Coriandrum sativum L. and Mimosa pudica L. leaves ethanol extract in lowering blood glucose and malondialdehyde (MDA) increased superoxide dismutase (SOD) in hyperglycaemic Wistar rats

Abstract

Introduction: Nano-mixture chitosan was used as a nano-extract framework, while tripolyphosphate was used as a stabilizer. Coriandrum sativum L. and Mimosa pudica L. nano extracts were created using the ionic gelatin technique. This study aimed to evaluate the effect of nano-mixture herbal extract of Coriandrum sativum L. and Mimosa pudica L. to lower free radicals and glucose levels in streptozotocin-induced hyperglycaemic rats. Methods: Fourier transformation infrared (FTIR) characterized the resultant nano-mixture extract. The antihyperglycemic characteristics of a nano-mixture extract were investigated in streptozotocin-induced rats using a randomized post-test-only control group design. At the same time, blood glucose levels and oxidative stress markers MDA and SOD were monitored. Results: Coriandrum sativum L. and Mimosa pudica L. extracts included polyphenols, flavonoids, alkaloids, and terpenoids, according to the results of the phytochemical test. Nano extract was well supported by PSA characterization as a delivery vehicle for bioactive chemicals, with a zeta potential of -23.98 mV and a particle size of 422.20 nm. The oral administration of the nano-mixture extract at a dose of 50 mg/Kg BW/day had the greatest results for lowering glucose blood MDA and raising SOD levels in hyperglycaemic rats, according to the antihyperglycemic test on streptozotocin-treated rats. Conclusion: In hyperglycaemic rats, a nano-mixture of Coriandrum sativum L. and Mimosa pudica L. nano extract may lower MDA and blood glucose while raising SOD levels.