Abstract
Analysis of tear fluid proteins: use of multiplex assays in profiling biomarkers of dry eye disease
Highlights
Some variation in IL-8 levels was noted in Dry eye disease (DED) subjects (246-4,391.5 pg/ml), but an overall trend for increased IL-8 was observed, compared to normals
Detectable levels of all 7 inflammatory proteins (IL1b, IL2, IL6, IL8, IL17, TNF-a and IFN-g) were observed in 2 DED subjects, a result not observed in normals
An increased IL-8 level in DED patients suggests a function in ocular surface inflammation
Summary
Analysis of tear fluid proteins: use of multiplex assays in profiling biomarkers of dry eye disease. Suzanne Hagan1,2*, Alan Tomlinson, Louise Madden, Anne M Clark, Katherine Oliver. Aims Dry eye disease (DED) is a distressing condition that is commonly associated with ageing, contact lens wear and autoimmune disease. DED is one of the fastest-growing eye disorders in older populations (over-50s) and is significantly underdiagnosed. Multiplex studies of tear fluids from DED patient have suggested a role for inflammatory cytokines in its pathology. We investigated tear fluids from DED and normal subjects for a panel of 7 cytokines, using the multiplex bead assay
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