Abstract
Aims Dry eye disease (DED) is a distressing condition that is commonly associated with ageing, contact lens wear and autoimmune disease. DED is one of the fastest-growing eye disorders in older populations (over-50s) and is significantly underdiagnosed. Multiplex studies of tear fluids from DED patient have suggested a role for inflammatory cytokines in its pathology. In this study, we investigated tear fluids from DED and normal subjects for a panel of 7 cytokines, using the multiplex bead assay.
Highlights
Multiplex studies of tear fluids from Dry eye disease (DED) patient have suggested a role for inflammatory cytokines in its pathology
An increased IL-8 level in DED patients suggests a function in ocular surface inflammation
Further studies may shed light on roles for the other 6 cytokines detected in 2 DED subjects
Summary
Analysis of tear fluid proteins: use of multiplex assays in profiling biomarkers of dry eye disease. Suzanne Hagan1,2*, Alan Tomlinson, Louise Madden, Anne M Clark, Katherine Oliver. Aims Dry eye disease (DED) is a distressing condition that is commonly associated with ageing, contact lens wear and autoimmune disease. DED is one of the fastest-growing eye disorders in older populations (over-50s) and is significantly underdiagnosed. Multiplex studies of tear fluids from DED patient have suggested a role for inflammatory cytokines in its pathology. We investigated tear fluids from DED and normal subjects for a panel of 7 cytokines, using the multiplex bead assay
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
