Analysis of Serum Cys-C, TBA, and Routine Blood Parameters of Patients with Hepatitis B-Related Decompensated Cirrhosis

Abstract

Objective: To study the levels of serum cystatin C (Cys-C), total bile acid (TBA), and other routine blood parameters on patients with decompensated hepatitis B cirrhosis. Methods: Study group 1 consisted of 30 patients with hepatitis B-related decompensated cirrhosis, and study group 2 consisted of 30 patients with hepatitis B; while the control group consisted of 30 healthy people who underwent physical examination. The blood parameters were used to evaluate the clinical treatment effect of patients. Results: The TBA, Cys-C, alanine transaminase (ALT), total bilirubin (TBIL), aspartate aminotransferase (AST), and international normalized ratio (INR) in study group 1 were significantly higher than those of study group 2 and the control group; while the platelet count (PLT), hemoglobin (Hb), albumin (ALB), and estimated glomerular filtration rate (eGFR) were significantly lower in the study group 1 compared to the control group and study group 2 (P < 0.05). The Cys-C, PLT, TBA, AST, TBIL, and INR of patients in study group 1 who were successfully treated were significantly lower than the patients who were not successfully treated (P < 0.05). Conclusion: Serum Cys-C, TBA, and routine blood parameters are useful in predicting the condition and the prognosis of patients of hepatitis B-related decompensated cirrhosis.