Therapeutic effects of glutathione combined with succinic acid adenosine methionine in the treatment of intrahepatic cholestasis of pregnancy

Abstract

Objective To evaluate the clinical value of succinic acid adenosine methionine and reduced glutathione in the treatment of intrahepatic cholestasis of pregnancy. Methods Sixty patients with intrahepatic cholestasis of pregnancy admitted in Sanmenxia Central Hospital from May 2015 to May 2018 were selected. According to the random number table method, they were divided into study group and control group, with 30 cases in each group. Patients in the control group were treated with succinic acid adenosine methionine on the basis of routine treatment. And patients in the study group were treated with reduced glutathione and succinic acid adenosine methionine on the basis of routine treatment. The changes of laboratory parameters, such as total bile acid (TBA), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and pregnancy outcomes were compared between the two groups. Results Before treatment, there was no significant difference in TBA, ALT or AST between the two groups (P>0.05); after treatment, the TBA, ALT and AST values of the two groups were lower than those before treatment, and the decline of the study group was more significant than that of the control group (P<0.05). The natural delivery rate was 73.33% (22/30) in the study group and 46.67% (14/30) in the control group (P<0.05). The rates of premature delivery and fetal distress in the study group were 3.33% (1/30) and 3.33% (1/30), which were lower than the 23.33% (7/30) and 23.33% (7/30) in the control group (P<0.05). Conclusions Combined application of reduced glutathione and succinic acid adenosine methionine in the treatment of intrahepatic cholestasis of pregnancy can promote the improvement of laboratory related indexes and effectively ensure the pregnancy outcomes of patients with intrahepatic cholestasis of pregnancy. Key words: Intrahepatic cholestasis of pregnancy; Glutathion; Succinic acid adenosine methionine