Analysis of serum concentrations of anti-epilepsy drugs in 113 case-times

Abstract

Objective To provide some references for clinical individualized mediaction analyzing the serum concentrations of anti-epilepsy drugs.Methods Enzyme-mutiplied immunoassay technique (EMIT)was used to determine the sermn concentrations of anti-epilepsy drugs in 113 case-times,then the concentrations were analyzed and compared with SPSS 16.0.The impact of age,sex,and drug combination on the serum concentrations of anti-epilepsy drugs and the relation between the serum concentrations of antiepilepsy drugs and therapeutic effect were analyzed.Results Among the serum concentrations of carbamazepine in 24 case-times,2 case-times whose diseases were totally controlled were lower than 4 μ g/ml;19 case-times between 4 and 12 μ g/ml,with an effective rate of 78.95％;3 case-times higher than 12 μ g/ml,with an effective rate of 66.67％.Among the serum concentrations of valproic acid in 74 case-times,24 case-times were lower than 50 μ g/ml,with an effective rate of 79.17％;43 case-times between 50 and 100 μ g/ml,with an effective rate of 81.40％;7 case-times higher than 100 μ g/ml,with an effective rate of 71.43％.Drug combination with carbamazepine had 13 case-times;61.54％ of the serum concentrations were within the effective range.Drug combination with valproic acid had 12 case-times;16.67％ of the serum concentrations were within the effective range.The impact of age,sex,and drug combination on the serum concentrations of anti-epilepsy drugs and the relation between serum concentration and therapeutic effect had no difference in statistics.Conclusions There are great individual differences among patients in the serum concentrations of antiepilepsy drugs.It is unilateral to adjust the dosage of drugs only depending on serum concentration.In clinical treatment,the serum concentrations of anti-epilepsy drugs are only references for adjusting drug dosage.We should adjust the drug dosage in term of the patients' conditions and the serum concentration of drug so that the patients will get the best therapeutic effect with a smallest drug dosage. Key words: Anti-epilepsy drugs; Serum concentration monitoring; Carbamazepine; Valproic acid