Analysis of serum biochemical indexes in patients with multiple system atrophy

Abstract

Objective To study changes in hepatic and renal function, serum lipids and homocysteine levels in patients with multiple system atrophy(MSA), and to explore the relationship of serum biochemical indexes with MSA and its severity. Methods A total of 86 hospitalized patients with MSA at our department from January 2014 to June 2017 were retrospectively analyzed.Eighty-five healthy subjects undergoing health physical examinations at our hospital during the same period were enrolled as a control group.Serum lipid levels and liver and renal function were compared between the two groups.After stratified by gender, the correlations of liver and renal function, serum lipids and homocysteine levels with MSA and its severity were analyzed. Results Serum levels of total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol were lower in the MSA group than in the control group(P 0.05). Conclusions Serum levels of lipids and urea are associated with MSA, but they are not independent risk factors for MSA or its severity.Gender may affect the occurrence of MSA, but it needs to be further confirmed. Key words: Multiple system atrophy; Dyslipidemias; Uric acid