Analysis of risk factors of coronary artery involvement in Takayasu arteritis

Abstract

Objective Coronary artery involvement is one of major causes of death in patients with Takayasu arteritis(TA) , we aim to search for potential risk factors of coronary artery involvement in patients with TA. Methods The clinical characteristics of 64 TA patients with involving coronary arteries and 73 TA patients without involving coronary arteries were retrospectively analyzed.The logistic regression analysis model was used to assess the relationship between potential risk factors and coronary artery disease. Results TA patients with coronary artery involvement were older and with later onset, higher prevalence of hyperlipidemia and diabetes mellitus.The multivariate logistic regression analysis showed that later onset of TA(OR=3.724, 95%CI: 1.289-10.763, P=0.015) was independently associated with coronary artery involvement in patients with TA. Conclusions Late-onset of TA is more likely to involve coronary arteries than early-onset of TA. Key words: Risk factors; Age of onset; Takayasu arteritis; Coronary artery involvement