Abstract

A total of 2090 cases of acute myocardial infarction and 63 cases of acute myocardial infarction combined with ventricular septal perforation were collected from Fuwai Huazhong Cardiovascular Hospital from September 2017 to January 2021. 189 cases of type 1 acute myocardial infarction were randomly selected according to the ratio of 1:3 as a control group, the patients collected and analyzed clinical data, the risk factors of AMI and VSR.

Highlights

  • Acute myocardial infarction (AMI) combined with ventricular septal rupture (VSR) is a rare but life-threatening complication

  • A total of 2090 cases of acute myocardial infarction and 63 cases of acute myocardial infarction combined with ventricular septal perforation (VSR group) were collected from Fuwai Huazhong Cardiovascular Hospital from September 2017 to January 2021. 1189 cases of type 1 acute myocardial infarction were randomly selected according to the ratio of 1:3 as a control group

  • This study shows that the admission hemoglobin, albumin, and serum chloride levels of patients with myocardial infarction combined with ventricular septal rupture are different from those of the control group, and there are few reports in the previous literature

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Summary

Introduction

Acute myocardial infarction (AMI) combined with ventricular septal rupture (VSR) is a rare but life-threatening complication. With the advent of the era of thrombolysis, the incidence of ventricular septal rupture after acute myocardial infarction has dropped significantly, only 0.17-0.31% [1,2]. Despite the decrease in incidence, the mortality (41-80%) and prognosis of such patients are still poor [1,5,6]. Basic research shows that matrix metalloproteinases and inflammatory cytokines play an important role in patients with ventricular septal rupture after myocardial infarction [9,10]. It is very important to identify and treat the perforation of the ventricular septum as soon as possible after acute myocardial infarction, which can significantly improve the prognosis of patients [11]

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