Abstract
The technique of high throughput or fast gel permeation chromatography was used to separate and quantify residual vinyl pyrrolidone monomer present in polyvinyl pyrrolidone polymer (PVP) and in a copolymer of vinyl pyrrolidone and vinyl caprolactam [P(VP/VCL)]. The chromatography exploits both size-exclusion and adsorption modes of separation. This methodology offers a single step analysis for residual vinyl pyrrolidone monomer as compared to multi-step and time-consuming reverse-phase chromatography measurements, yielding similar results. Fast GPC and reverse-phase analyses are quantitatively compared and reported using both typical industrial and European Pharmacopeia methodologies for HPLC. The results of this study demonstrate that fast gel permeation chromatography presents a viable option to traditional reverse- phase chromatography in the quantitative analysis of residual vinyl pyrrolidone monomer.
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