Analysis of residual solvents by fast gas chromatography

Abstract

Using a 10 m×0.1 mm I.D. DB-624 capillary column, fast separation of 40 commonly used solvents can be achieved in a single analysis in less than 4.9 min. For typical determination of trace solvents in drug substance, the analysis time can further be shortened to less than 1.5 min using combined temperature and pressure programming. The technique was illustrated for sample introduction by both direct injection and via headspace.