Abstract
A simple and reliable method has been developed for the determination of residual solvents in drug substances by gas chromatography with thermal desorption cold trap injection. Residual solvents in a sample were desorbed by heating at a temperature higher than the melting point of the sample, then trapped in a cold trap cooled at -130°C. After the cold trap was heated, solvents were injected into an analytical column. These operations were performed automatically by the control unit of the injector. This method is useful for the determination of residual solvents in drug substances because of its high sensitivity without the interference of drug substances. As an example of the application of the method, residual solvents in five drug substances were determined.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
