Analysis of remote results of treatment of patients with maxillary sinus cancer

Abstract

Maxillary sinus cancer is one of the most complex malignancies to treat and has an unfavorable prognosis for long-term outcomes. The purpose of the study: based on the evaluation of long-term treatment outcomes (mortality, survival) to analyze the effectiveness of treatment of patients with maxillary sinus cancer and other factors which influence the outcome, including the level of expression of molecular markers. Object and methods: Long-term results of surgical treatment of 103 patients with maxillary sinus cancer stage II-IV (T2-4N0-3M0) were evaluated, which was performed in the ENT oncology department of І.І. Mechnikov Dnipropetrovsk Regional Clinical Hospital over the period of 2011-2017. Remote follow-up of patients was conducted until 2019. Results: The effectiveness of the treatment is confirmed by the analysis of survival in the studied sample: annual survival of 87.36% (95% CI 80.94-93.78); three-years’ survival – 42.75% (95% CI 33.2-52.3); five-years’ survival – 19.76% (95% CI 12.07-27.45); median survival – 32.13 (95% CI 27.0-53.0) months. Using a regression analysis of the proportional risks by Cox, it was proved that patients with recurrences of thyroid cancer die from cancer 3.13 times more often (p=0.009) than individuals in whom cancer was not accompanied by recurrence, with increasing expression of the marker TIMP-1 per unit the risk of adverse outcomes for patients is reduced by 2.56 times (p=0.034). Conclusions: Evaluation of long-term treatment outcomes (mortality, one-, three-, and five-years’ survival) of patients with maxillary sinus cancer has proven the effectiveness of treatment and approaches to their determination.