Abstract
To analyze the relationship between a prethrombotic state and the occurrence of thrombosis, as well as survival time for patients with cervical cancer. Patients with first diagnosis of cervical cancer were subgrouped according to FIGO staging, and two D-dimer levels were assessed. According to the results, patients are divided into an observation group (abnormal) and control group (normal). For 106 patients with cervical cancer, 38 with abnormal D-dimer, the abnormal rate is 35.9%, of which stage I accounted for 6.5%, stageII 38.5%, stage III 50%, and stage IV 61.1% (p=0.013); The level of D-dimers in stageI wass 0.87±0.68ug/ ml, while in stage II it was 1.50±1.35ug/ml, stage III 2.60±1.86ug/ml and stage IV 18.6±53.4ug/ml (P=0.031); after follow-up of patients for 2-30 months, the mortality of observation group is 21.1%, while for control group it was 2.94% (p <0.01). In the observation group, survival time was 15.1±5.8 months, while for control group it was 21.0±5.4 months, the difference between two groups being highly significant (p=0.000). There is a direct correlation between prethrombotic state and the grade malignancy of cervical cancer. The level is positively correlated with clinical stage, and is inversely related to survival time, so that a prethrombotic state could be used to predict the prognosis for patients with cervical cancer.
Highlights
Prothrombotic state, known as hyper-coagulable state, refers to a pathological process of hemostasis, coagulation and fibrinolysis disorders caused by multiple factors (Linkins et al, 2013)
For 106 patients with cervical cancer, 38 with abnormal D-dimer, the abnormal rate is 35.9%, of which stage I accounted for 6.5%, stageII 38.5%, stage III 50%, and stage IV 61.1% (p=0.013); The level of D-dimers in stageI wass 0.87±0.68ug/ ml, while in stage II it was 1.50±1.35ug/ml, stage III 2.60±1.86ug/ml and stage IV 18.6±53.4ug/ml (P=0.031); after follow-up of patients for 2-30 months, the mortality of observation group is 21.1%, while for control group it was 2.94% (p
The level is positively correlated with clinical stage, and is inversely related to survival time, so that a prethrombotic state could be used to predict the prognosis for patients with cervical cancer
Summary
Prothrombotic state, known as hyper-coagulable state, refers to a pathological process of hemostasis, coagulation and fibrinolysis disorders caused by multiple factors (Linkins et al, 2013). The mergence of malignant tumor and pro-thrombotic state is the root cause of thrombus formation and hypercoagulable state is related to the invasion and transference of malignant tumor (Khosa et al, 2010). D-dimer, a specific degradation products of fibrin monomer which have experienced the cross-linking to activating factor and the hydrolysis of plasmin, is the molecular marker of coagulation and fibrinolysis activation. Its level increase reflects the dual activation of blood coagulation and fibrinolysis system and it could be used as a specific marker of fibrin formation in blood vessels as well as a hyper-coagulable and fibrinolytic sign (Zhang et al, 2012). Adopting the prospective clinical study method, this paper studies the relationship between pro-thrombotic state andervical cancer clinical staging as well as the survival time by detecting D- dimer of patients with cervical cancer
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