Analysis of related factors of severe infectious diarrhea in hospitalized pediatric patients with leukemia

Abstract

Objective To explore the related factors of severe infectious diarrhea in hospitalized pediatric patients with leukemia, and to suggest preventive nursing countermeasures. Methods Totally 81 pediatric patients, which were diagnosed with infectious diarrhea in hospitalized pediatric patients with leukemia in Shanghai Children′s Medical Center from July 2016 to December 2017,were collected and analyzed. Univariate analysis and multivariate Logistic regression analysis was carried out on the related factors affecting severe infectious diarrhea. Results There were 36 cases (44.4%) of severe infectious diarrhea occurred in 81 patients with infectious diarrhea. Multivariate Logistic regression analysis showed that the history of diarrhea (OR=3.887) and the long duration of diarrhea with neutropenia (OR=1.243) were risk factors for severe infectious diarrhea in hospitalized children with leukemia (P<0.05). And the results also showed that the bigger age (OR=0.799) and the newly diagnosed leukemia (OR=0.236) were the protective factors for severe infectious diarrhea in in hospitalized children with leukemia (P<0.05). Conclusion Prevention and treatment of diarrhea should be emphasized in pediatric patients with leukemia since newly diagnosis, and bone marrow depression should be actively ameliorated. Among those patients, smaller age and patients with repeated chemotherapy were at high risk for severe infectious diarrhea, which should be paid more attention. Key words: Leukemia; Diarrhea; Factor analysis; Statistical