Curative effects of Saccharomyces boulardii adjuvant therapy on infectious diarrhea in adults

Abstract

Objective To observe the effects of Saccharomyces boulardii adjuvant therapy in the treatment of infectious diarrhea in adults. Methods A total of 200 adult patients with infectious diarrhea admitted to the Yuncheng Central Hospital from January 2014 to October 2018 were divided into experimental group and control group by the random number table method, with 100 cases in each group. Patients in experimental group were treatment with Saccharomyces boulardii combined with levofloxacin, while patients in control group were treatment with levofloxacin. The total effective rate, improvement of symptoms (daily defecation frequency, diarrhea duration) before treatment and 3 days after treatment, and related indicators of immune function (T lymphocytes CD4+ , CD8+ , CD4+ /CD8+ ) andserum inflammatory factors, including tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), endotoxin, before treatment and 5 days after treatment were compared between the two groups. Results The total effective rate of treatment in experimental group (92.00%) was significantly higher than that in control group (66.00%), and the difference was statistically significant (P<0.05). The daily defecation frequency of control group and experimental group were (1.53±0.16)d and (1.45±0.13)d, respectively 3 days after treatment, which were lower than the (6.73±1.21)d, (6.75±0.92)d before treatment (all P<0.05), and the change was more significant in experimental group (P<0.05). The diarrhea duration in experimental group was (1.64±0.32)d, significantly shorter than the (2.17±0.28)d in control group (P<0.05). The levels of CD4+ and CD4+ /CD8+ in the two groups 5 days after treatment were increased compared with those before treatment (all P<0.05); and the CD8+ levels in the two groups were reduced compared with that before treatment (all P<0.05); and the changes of above indexes were more significant in experimental group (all P<0.05). The levels of TNF-α, IL-1β, CRP and endotoxin in the two groups were significantly than before treatment (all P<0.05), and the levels in experimental group were significantly lower than those in control group (all P<0.05). Conclusions Saccharomyces boulardii adjuvant therapy for adult infectious diarrhea can enhance the efficacy, improve patient’s immune function and relieve the inflammatory response. Key words: Saccharomyces boulardii; Levofloxacin; Adults; Infectious diarrhea; Clinical efficacy