Abstract
Oxygen transport to multiple “non-obstructive” plaque regions in main coronary arteries of man was examined by numerically solving the oxygen transport equation for convective and diffusive processes in the lumen for actual variations of blood flow rate and the velocity field during the cardiac cycle. Oxygen transport to the wall varied significantly along the arterial section, was strongly dependent upon the various flow regions that occurred, and varied considerably during the cardiac cycle. A drastic reduction in oxygen transport to the arterial wall occurred at the incipient separation location on the back side of a plaque where it is believed that the lumen side resistance to oxygen transport is at least an order of magnitude greater than the inner avascular wall resistance, and therefore the availability of oxygen for cellular respiration is essentially boundary layer controlled. In vivo measurements with oxygen microelectrodes in animals are needed to learn more about variations of oxygen transport in plaque regions, in particular on the back side of plaques where hypoxia may occur.
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