Abstract
OXA-48-like beta-lactamase producing bacteria are now endemic in several European and Mediterranean countries. Among this carbapenemase family, the OXA-48 and OXA-181 variants predominate, whereas other variants such as OXA-204 are rarely reported. Here, we report the molecular epidemiology of a collection of OXA-204-positive enterobacterial isolates (n = 29) recovered in France between October 2012 and May 2014. This study describes the first outbreak of OXA-204-producing Enterobacteriaceae in Europe, involving 12 isolates of an ST90 Escherichia coli clone and nine isolates of an ST147 Klebsiella pneumoniae clone. All isolates co-produced the cephalosporinase CMY-4, and 60% of them co-produced the extended-spectrum beta-lactamase CTX-M-15. The bla OXA-204 gene was located on a 150-kb IncA/C plasmid, isolated from various enterobacterial species in the same patient, indicating a high conjugative ability of this genetic vehicle.
Highlights
Since the 2000s, the carbapenem-hydrolysing betalactamase OXA-48 has rapidly and widely disseminated and is endemic in several European and Mediterranean countries [1,2,3,4]
These isolates were sent to the National Reference Centre (NRC) because they exhibited decreased susceptibility to carbapenems and/or because they were isolated from a patient who was identified in epidemiological investigations around an infected or colonised patient
We analysed different features of the OXA-204positive enterobacterial isolates collected between October 2012 and May 2014 at the NRC for Antibiotic Resistance, France
Summary
Since the 2000s, the carbapenem-hydrolysing betalactamase OXA-48 has rapidly and widely disseminated and is endemic in several European and Mediterranean countries [1,2,3,4]. The second group of OXA-48-like variants includes beta-lactamases with extended-spectrum hydrolysis properties and without any significant carbapenemase activity because of deletions in the active site of the enzyme, such as OXA-163, OXA-247, or OXA-405 [11,12,13]. In most of these cases, the blaOX - A-48 like genes are plasmid-borne and are associated with insertion sequences involved in their mobilisation and expression [1,7,9]
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