Abstract

BackgroundEnd-stage renal disease (ESRD) confers a large health-care burden for the United States, and the morbidity associated with vascular access failure has stimulated research into detection of vascular access stenosis and low flow prior to thrombosis. We present data investigating the possibility of using differential pressure (ΔP) monitoring to estimate access flow (Q) for dialysis access monitoring, with the goal of utilizing micro-electro-mechanical systems (MEMS) pressure sensors integrated within the shaft of dialysis needles.MethodsA model of the arteriovenous graft fluid circuit was used to study the relationship between Q and the ΔP between two dialysis needles placed 2.5–20.0 cm apart. Tubing was varied to simulate grafts with inner diameters of 4.76–7.95 mm. Data were compared with values from two steady-flow models. These results, and those from computational fluid dynamics (CFD) modeling of ΔP as a function of needle position, were used to devise and test a method of estimating Q using ΔP and variable dialysis pump speeds (variable flow) that diminishes dependence on geometric factors and fluid characteristics.ResultsIn the fluid circuit model, ΔP increased with increasing volume flow rate and with increasing needle-separation distance. A nonlinear model closely predicts this ΔP-Q relationship (R2 > 0.98) for all graft diameters and needle-separation distances tested. CFD modeling suggested turbulent needle effects are greatest within 1 cm of the needle tip. Utilizing linear, quadratic and combined variable flow algorithms, dialysis access flow was estimated using geometry-independent models and an experimental dialysis system with the pressure sensors separated from the dialysis needle tip by distances ranging from 1 to 5 cm. Real-time ΔP waveform data were also observed during the mock dialysis treatment, which may be useful in detecting low or reversed flow within the access.ConclusionWith further experimentation and needle design, this geometry-independent approach may prove to be a useful access flow monitoring method.

Highlights

  • End-stage renal disease (ESRD) confers a large health-care burden for the United States, and the morbidity associated with vascular access failure has stimulated research into detection of vascular access stenosis and low flow prior to thrombosis

  • The recently updated National Kidney Foundation (NKF) Dialysis Outcomes and Quality Initiative (DOQI) recommendations have reaffirmed the recommendation for monitoring using monthly measurement of flow or static venous pressure as the preferred methods.[8]

  • Our group is investigating the possibility of using differential pressure (ΔP) monitoring to estimate access flow for dialysis access monitoring, with the current study aimed at developing and testing an access geometry-independent algorithm that is convenient to perform throughout dialysis or at least at every dialysis session

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Summary

Introduction

End-stage renal disease (ESRD) confers a large health-care burden for the United States, and the morbidity associated with vascular access failure has stimulated research into detection of vascular access stenosis and low flow prior to thrombosis. We present data investigating the possibility of using differential pressure (ΔP) monitoring to estimate access flow (Q) for dialysis access monitoring, with the goal of utilizing micro-electro-mechanical systems (MEMS) pressure sensors integrated within the shaft of dialysis needles. Dialysis access blood volume flow and pressure may be helpful parameters in end-stage renal disease (ESRD) vascular access monitoring. Frequent and convenient flow estimations may improve monitoring by determining each patient's mean access flow and standard deviation in flow. This would allow the change in access blood flow with ultrafiltration and blood pressure reduction to be followed, just as blood pressure and various machine parameters are followed during dialysis. Several engineering problems must be addressed to make this approach clinically practical

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