Analysis of Mental State of Patients after Drug Addiction and Withdrawal Guided by PETCT Image Based on Optimized Image Fusion Algorithm

Gustavo Ramirez,Xiang Peng,Yaowen Pang

doi:10.1155/2021/5943410

Gustavo Ramirez, Xiang Peng + Show 1 more

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https://doi.org/10.1155/2021/5943410

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Abstract

Blood oxygen level-dependent functional magnetic resonance imaging (BOLD-fMRI) studies have shown that drug-dependent patients are activated in different addictive brain areas under the stimulation of relevant environmental cues, which in turn leads to craving and relapse. This study uses magnetic resonance spectroscopy to measure brain temperature to explore the brain temperature changes in different addictive brain regions of heroin and methamphetamine addicts in a short-term withdrawal state and to explore whether the quantitative index of brain temperature change can be used as a diagnostic drug Methods. The subjects were scanned by resting-state MRI spectroscopy first and then subjected to MRI spectroscopy scanning under visual stimulation. The subjects were required to watch the heroin/meth-related clue pictures carefully during visual stimulation. The measured chemical shift value of N-acetyl-aspartic acid (NAA) is substituted into the brain temperature calculation formula T = 37 + 100 to obtain the brain temperature before and after visual stimulation. In addition, the anxiety and depression states of heroin and methamphetamine-dependent patients were evaluated. Results. There was no statistically significant change in the brain temperature of the prefrontal cortex before and after visual stimulation in heroin and methamphetamine-dependent subjects; compared with the normal group, there was no change in prefrontal cortex brain temperature before and after visual stimulation in heroin and methamphetamine-dependent subjects. Statistical Significance. The changes of hippocampal temperature before and after visual stimulation in methamphetamine-dependent patients were not statistically significant; compared with the normal group, there was no statistically significant difference in the changes of hippocampal temperature before and after visual stimulation in methamphetamine-dependent patients. Conclusion. This study initially found that the visual cues related to heroin and methamphetamine were not enough to cause significant changes in the brain temperature of the prefrontal cortex.

Highlights

Drug dependence can produce corresponding physiological, cognitive, and behavioural symptoms
E prefrontal cortex spectrum curves of the heroin group before and after visual stimulation and the matched normal group are shown in Figures 4 and 5. e spectrum curves of the prefrontal cortex, left hippocampus, and right hippocampus of the methamphetamine group and the matched normal group are shown in Figures 6 and 8. e figure shows NAA chemical shift values before and after visual stimulation in the heroin group, methamphetamine group, and normal group
magnetic resonance spectroscopy (MRS) measurement of brain temperature has been reported in the research of stroke and traumatic brain injury, and there has not been any research on the application of MRS measurement of brain temperature in the field of drug addiction

Summary

Introduction

Drug dependence can produce corresponding physiological, cognitive, and behavioural symptoms. Dependents are aware of the harm caused by addictive substances but still involuntarily continue to use them, leading to increased drug tolerance and inducing impulsive drug-seeking behaviour, resulting in serious withdrawal symptoms. Drug dependence has the characteristics of chronic and recurrent episodes. Drug-dependent persons in the withdrawal period are prone to craving and relapse under the induction of drug clues. Erefore, how to completely eliminate drug addiction has become a difficult point in clinical treatment. Drug abuse and dependence are a worldwide public health problem, which seriously threatens human life and health. E abuse of heroin, the traditional drug, has become the most serious public health problem in China. Its addiction can extensively damage the neurocognitive functions of the brain, including damage to inhibitory

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