Analysis of magnetic field impact on nanoparticles used in nanomedicine and a measurement approach

Abstract

Nanomedicine, in particular the use nanoparticles for drug delivery (DD), is an increasing field of development and advancement. The influence and the interference of magnetic field about delivery action is an important field of investigation. Vaccines and specific drugs for known and rare pathologies can get benefits from this approach. The main goal of the work is to provide a modelling that can support the know-how of the impact of a magnetic field about the delivery of drug allocated on Nanoparticles (NPs), thus defining guidelines to measure the delivery function for generic biocompatible NPs. In particular, by means of Finite Element Method (FEM) approach, the impact magnetic field, on gold nanoparticle (GN), used in nanomedicine for DD process, is analysed to facilitate the knowledge of the delivery mechanisms. The study is addressed to the estimation of the magnetic field distribution on the GNs interface, supporting the efficacy of the magnetic field stimulation. The paper is concluded by discussing measurement approaches useful to define guidelines. The main goal of the paper is to provide a methodology to understand DD phenomena in nanotechnology using a magnetic field as stimuli, by defining at the same time tools and approaches tailoring a measurement protocol in nanotechnology.