Analysis of M1 and M2 tumor associated macrophages in tongue squamous cell carcinomas.

Silvia Agarbati,Lorenzo Lo Muzio,Giuseppina Campisi,Marco Mascitti,Francesca Fazioli,Corrado Rubini

doi:10.3389/conf.fphys.2019.27.00026

Abstract

Analysis of M1 and M2 tumor associated macrophages in tongue squamous cell carcinomas.

Highlights

This study included surgical specimens obtained from 71 patients with tongue squamous cell carcinoma (TSCC) (36 graded as G1 and 35 graded as G3). 4-μm serial sections from formalin-fixed, para n embedded blocks were cut for each case and mounted on poly-L-lysine-coated glass slides
Tumor associated macrophages (TAMs) are the dominant leukocyte population found in the tumor microenvironment and their mobilization into tumor tissues is a critical event in tumor initiation, growth, and development
TAMs have been detected in head and neck cancers, little is known about their phenotype in the context of the tongue squamous cell carcinoma (TSCC), which have the highest incidence in maxillofacial malignant tumors

Summary

Introduction

This study included surgical specimens obtained from 71 patients with TSCC (36 graded as G1 and 35 graded as G3). 4-μm serial sections from formalin-fixed, para n embedded blocks were cut for each case and mounted on poly-L-lysine-coated glass slides. Analysis of M1 and M2 tumor associated macrophages in tongue squamous cell carcinomas Tumor associated macrophages (TAMs) are the dominant leukocyte population found in the tumor microenvironment and their mobilization into tumor tissues is a critical event in tumor initiation, growth, and development.

Results

Conclusion