Analysis of immune-phenotype in squamous cells carcinoma of the tongue

Abstract

Event Abstract Back to Event Analysis of immune-phenotype in squamous cells carcinoma of the tongue Marco Mascitti1, Giuseppe Troiano2*, Rodolfo Mauceri3, Lorenzo Lo Muzio2, Corrado Rubini1 and Andrea Santarelli1 1 Polytechnical University of Marche, Department of Clinical Specialistic and Dental Sciences, Italy 2 University of Foggia, Department of Clinical and Experimental Medicine, Italy 3 University of Palermo, Department of Surgical, Oncological and Oral Sciences, Italy Aim. The recent success in the treatment of head and neck squamous cell carcinoma with checkpoint inhibitors has stimulated researchers in the understanding of the role that the immune system plays in cancer. The immune system interacts intimately with tumors over the entire process of disease development and progression to metastasis. Recently, Chen and Mellman classified cancer in relation to the immune system, distinguishing three phenotypes: Inflamed, Immune-escaped and Immune-desert. In this paper, we analyzed tongue squamous cell carcinoma (TSCC) samples, according to the aforementioned classification, in order to study the role of the immune system in this subtype of tumors. Materials and Methods. In this study, 82 patients surgically treated for SCCTs at the Department of Maxillofacial Surgery, “Ospedali Riuniti” General Hospital (Ancona, Italy), between 2011 and 2016 were included. Clinical and radiologic data were obtained from each patient’s medical record, and pathologic data were retrieved from the archives of the Sections of Pathology, Marche Polytechnic University, Italy. Tumors were classified on the basis of the immune infiltrated in: Inflamed, Immune-escaped and Immune-desert; and correlated with clinic pathological parameters. Results. Pathological analysis of immune-phenotype of TSCC samples revealed that: 59.8% (49/82) were classified as Inflamed, 30.5% (25/82) as Immune-Excluded and 9.8% (8/82) as Immune-desert. In addition, the ratio carcinoma stroma in TSCC inversely correlated with the size of the tumor at the time of diagnosis. Discussion. The analysis of the immune-phenotype could be used to further stratify patients with TSCC. A possible inclusion of this parameter in the clinical staging needs to be evaluated in further well-standardized studies. References Chen DS, Mellman I. Elements of cancer immunity and the cancer-immune set point. Nature. 2017 Jan 18;541(7637):321-330. Cogdill AP, Andrews MC, Wargo JA. Hallmarks of response to immune checkpoint blockade. Br J Cancer. 2017 Jun 27;117(1):1-7. Chen DS, Mellman I. Oncology meets immunology: the cancer-immunity cycle. Immunity. 2013 Jul 25;39(1):1-10. Keywords: OSCC (oral squamous cell carcinoma), head and neck, Immunity, Immune System, Tongue Conference: 5th National and 1st International Symposium of Italian Society of Oral Pathology and Medicine., Ancona, Italy, 19 Oct - 20 Oct, 2018. Presentation Type: Poster Presentation Topic: Oral Diseases Citation: Mascitti M, Troiano G, Mauceri R, Lo Muzio L, Rubini C and Santarelli A (2019). Analysis of immune-phenotype in squamous cells carcinoma of the tongue. Front. Physiol. Conference Abstract: 5th National and 1st International Symposium of Italian Society of Oral Pathology and Medicine.. doi: 10.3389/conf.fphys.2019.27.00020 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 24 Oct 2018; Published Online: 09 Dec 2019. * Correspondence: Dr. Giuseppe Troiano, University of Foggia, Department of Clinical and Experimental Medicine, Foggia, Apulia, 71122, Italy, giuseppe.troiano@unifg.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Marco Mascitti Giuseppe Troiano Rodolfo Mauceri Lorenzo Lo Muzio Corrado Rubini Andrea Santarelli Google Marco Mascitti Giuseppe Troiano Rodolfo Mauceri Lorenzo Lo Muzio Corrado Rubini Andrea Santarelli Google Scholar Marco Mascitti Giuseppe Troiano Rodolfo Mauceri Lorenzo Lo Muzio Corrado Rubini Andrea Santarelli PubMed Marco Mascitti Giuseppe Troiano Rodolfo Mauceri Lorenzo Lo Muzio Corrado Rubini Andrea Santarelli Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.