Analysis of invasive realted factors in patients with growth hormone-secreting adenoma

Abstract

Objective To assess the relationship between preoperative GH levels,tumor size,gender,age and tumor invasiveness of growth hormone-secreting adenoma.Methods Twenty-two initial treated patients with growth hormone (GH) adenomas were collected.All patients were tested preoperative GH,analyzed age composition,gender differences and the tumor size of MRI.The invasiveness of pituitary adenomas were judged according to Hardy' s classification scheme modified by Wilson.Results Logistic regression analysis indicated that the incidence of invasive adenomas in patients with a larger tumor was 17.981 times higher than that of patients with a smaller tumor.The invasiveness of tumor had no relationship with preoperative GH levels,gender,age.The size of invasive adenomas and that of non-invasive adenomas was statistically significant(P ＜ 0.01).Conclusions The invasiveness of tumor is closely related to the size,is not related to the preoperative PRL levels,age and the gender. Key words: Growth hormone adenoma ; Growth hormone ; Invasiveness