Abstract
Aim - to analyze the effect of rutin on the renal excretory function in the conditions of normogravity and hypergravity. Materials and methods. 9 series of experiments were conducted, including 4 series with the use of a centrifuge of ultra-short radius. The effect of rutin in the dose of 10 mg/kg on the renal excretory function was studied in normal conditions and in combination with the gravity action 3g. All the animals received 3% water load intragastrically and were placed into exchange cages for 24 hours. We obtained urine samples and determined the amount and the concentration of sodium, potassium and creatinine. Results. It was found that under normal conditions rutin, administered intragastrically in a dose of 10 mg/kg, promotes significant increase in diuresis and saluresis solely due to the inhibition of tubular reabsorption. Rutin in a dose of 10 mg/kg in combination with the gravity action enhances its original diuretic activity by complex influence on tubular and glomerular kidney structures. Rutin alone and rutin in combination with hypergravity stimulates the excretory function of the kidneys similarly to hydrochlorothiazide, but has a shorter latent period. Conclusion. The use of rutin combined with the gravity action contributes to the stimulation of the renal excretory function not only due to the tubular component, but also due to the glomerular one.
Highlights
The effect of rutin in the dose of 10 mg/kg on the renal excretory function was studied in normal conditions and in combination with the gravity action 3g
The use of rutin combined with the gravity action contributes to the stimulation of the renal excretory function due to the tubular component, and due to the glomerular one
Участие авторов: Концепция и дизайн исследования: Зайцева Е.Н., Дубищев А.В., Куркин В.А
Summary
Цель — проанализировать действие рутина на выделительную функцию почек в условиях нормогравитации и гирпергравитации. Было изучено влияние рутина в дозе 10 мг/кг на экскреторную функцию почек в обычных условиях и в сочетании с гравитационным воздействием 3g. Рутин в дозе 10 мг/кг в сочетании с гравитационным воздействием усиливает свою исходную диуретическую активность, воздействуя комплексно на канальцевые и на клубочковые структуры почек. Применение рутина в сочетании с гравитационным воздействием способствует стимуляции экскреторной функции почек не только за счет канальцевого компонента механизма действия, но и за счет клубочкового. Aim — to analyze the effect of rutin on the renal excretory function in the conditions of normogravity and hypergravity. The effect of rutin in the dose of 10 mg/kg on the renal excretory function was studied in normal conditions and in combination with the gravity action 3g. We obtained urine samples and determined the amount and the concentration of sodium, potassium and creatinine
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