Analysis of impact factors on prognosis of patients with gallbladder adenocarcinoma after surgery

Abstract

Objective To study the impact factors on prognosis of patients with gallbladder adenocarcinoma after surgery. Methods The clinicopathological data of 1 285 patients who underwent surgery and were histologically confirmed to have gallbladder adenocarcinoma from 2004 to 2014 was extracted from the SEER database of US National Cancer Institute. Life table was used to calculate the survival rate. Kaplan-Meier was used to construct the survival curves. Univariate and Cox multivariate regression analysis were applied to evaluate the prognostic factors. The univariate analysis was evaluated by the log-rank χ2 test. Results The median survival of 1 285 patients with gallbladder adenocarcinoma was 32 months. The 1-, 3- and 5-year survival rates were 77.5%, 46.8% and 36.5%, respectively. The 5-year survival rates of stage Ⅰ, Ⅱ, ⅢA, ⅢB, ⅣA, ⅣB were 72.7%, 63.2%, 24.6%, 20.5%, 0 and 5.1%, respectively. The median survival of stage ⅢA, ⅢB, ⅣA and ⅣB were 22 months, 19 months, 12 months and 16 months, respectively. The differences were statistically significant (P 0.05). Multivariate Cox regression analysis showed that sex (male), age (≥65 years), degree of differentiation, T staging, number of lymph nodes detected (<4) and AJCC staging were independent risk factors affecting prognosis of patients with gallbladder adenocarcinoma (P<0.05). Conclusions With increase in AJCC staging, the survival rates in patients with gallbladder adenocarcinoma after surgery decreased gradually. Parameters including sex, age, T staging, number of lymph nodes detected and AJCC staging were independent factors affecting prognosis of patients with gallbladder adenocarcinoma after surgery. Key words: Gallbladder neoplasms; Neoplasm staging; Gallbladder adenocarcinoma; Prognosis; Survival