Abstract
ART decreases the viral load to a minimum level and retains this level for a long time, however, an increase in the number of CD4 lymphocytes is not always determined, which indicates the lack of immunological success of ART. Despite the long-term use of ART, this category of patients retains an immunodeficiency state and, as a result, an increased risk of the onset of AIDS.
Highlights
Clinical course of HIV-infection is characterized by a long-term period with possible various opportunistic infections and an increase in the number of concomitant diseases [10, 7-18; 5, 368] and comorbid conditions [8, 292-6]
Antiretroviral therapy decreases the viral load to a minimum level and keep this viral load level for a long time, an increase in the number of CD4 lymphocytes is not always determined [4, 152160; 6, 1-5]
After three years after prescription of antiretroviral therapy (ART), depending on the initial CD4 lymphocyte counts, it was found that in the group of patients with CD4 lymphocytes below 50 cells / μL, viral load decrease less than 500 RNA copies / ml was observed in all patients, except one patient
Summary
Retrospective study of the outpatient cards, which include 455 HIV-positive patients registered at the Republican AIDS Center and receiving ART on different periods of the disease was carried out. The diagnosis was confirmed clinically and laboratory by ELISA and immunoblotting
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