Analysis of IL-1α(−889) and IL-1B(+3953) Gene Polymorphism in Syrian Patients with Aggressive Periodontitis: A Pilot Study

Kenan Shibani,Razan Khattab,Reem Shhab

doi:10.5402/2011/682564

Abstract

Polymorphisms in IL-1 gene have been suggested to influence transcription of IL-1α and IL-1B and thereby the pathophysiology of periodontitis. Using genotyping IL-1 test, a pilot study was conducted on 32 Syrian patients with aggressive periodontitis (AgP) and 35 healthy controls to investigate the association between the IL-1α(−889), IL-1B(+3953) gene polymorphisms and AgP among schoolchildren. The results revealed a similar distribution of genotypes between patients and controls, and did not support an association between IL-1 gene polymorphisms and AgP, however, the association was significant in male patients only. To determine and confirm any susceptible or resistant genes for AgP, future studies should use many target genes and well-defined related periodontal outcomes.

Highlights

Periodontitis is an opportunistic inflammatory disease of the periodontium
Studies have demonstrated that periodontitis is associated with elevated levels of inflammatory cytokines [2], which have a substantial impact on numerous biological activities, and they are taking part in triggering inflammatory cascades and systems [3]
Aggressive periodontitis is a multifactorial disease resulting from the complex interactions between the host, microorganisms, and environment

Summary

Introduction

Periodontitis is an opportunistic inflammatory disease of the periodontium. It is widely regarded as one of the most common diseases worldwide. Studies have demonstrated that periodontitis is associated with elevated levels of inflammatory cytokines [2], which have a substantial impact on numerous biological activities, and they are taking part in triggering inflammatory cascades and systems [3]. Interleukin-1 (IL-1) is considered a major mediator of periodontal inflammation. It affects nearly every cell type, often in concert with other cytokines or small mediator molecules (e.g., phospholipase A2 type II, cyclooxygenase-2(cox2)). IL-1 family genes are located in a cluster on human chromosome 2q13, a specific genotype in the IL-1 cluster that includes a specific locus is associated with increased IL-1 production and increased susceptibility to periodontitis [7]

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