Abstract
Analysis of the function of individual neurons and immune cells (B lymphocytes) has been enormously profitable for the understanding of the nervous and immune systems. Indeed, specialization of individual cells is central to theories underlying the function of those systems. In contrast, homogeneity among cells subserving various functions in endocrine and exocrine secretory systems is the common assumption. These differences in viewpoint may arise simply from the availability of methods for the study of individual neurons (single unit electrical recordings) and immune cells (hemolytic plaque assay for detection of antibody secretion) on the one hand, and their absence for individual endocrine and exocrine cells, on the other. Thus, the extent to which heterogeneity in cell function contributes to the function of endocrine and exocrine systems is unknown.
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