Abstract
Objective The study aimed to investigate the Human leukocyte antigen (HLA) class Ⅰ and class Ⅱ genes haplotypes and their clinical implications in Hepatitis B virus (HBV) infections in combination with HBV subgenotype C2.Methods In this study,230 HBV infections were compared to 210 healthy,unrelated Han subjects for their HLA haplotype.All the groups performed the HLA alleles typing and haplotype analysis.Results The results revealed that A * 02-B * 40 was the most common haplotype in Northeast China,A * 02-DRB1 * 12 and A * 02-B * 15-DRB1 * 09 cartier were susceptible to infected with HBV.A * 02-DRB1 * 12 might be in association with viral persistence.When infected with HBV-C2 subgenotype,A * 24-DRB1 * 14,B * 15-DRB1 * 04 and A * 02-B * 15,A * 02-DRB1 * 15 and A * 02-B15DRB1 * 09 carrier always followed by an acute clinical course and was more susceptible to recovery from the diseases.Conclusions The data in this study presented a link between HLA haplotypes and HBV pathogenesis and suggested potential therapeutic targets for hepatitis B. Key words: Hepatitis B virus (HBV); HBV infection; HBV subgenotype; Human leukocyte antigen (HLA)
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call