Abstract
Background:NADC30-like strains of porcine reproductive and respiratory syndrome virus first appeared in Chinese swine herds in 2012.Objective and Method:To explore the possible genetic diversity of these strains, we sequenced and analyzed the complete genomes of two NADC30-like strains. These isolates shared 95.4% homology with NADC30.Result:The two strains displayed a discontinuous deletion of 131 amino acids in NSP2, mutations of amino acids in GP3 and GP5, and a 3-nucleotide deletion in the 3′ untranslated region. Phylogenetic analysis showed that the two isolates formed a new branch and clustered in a subgroup with NADC30 isolates from North America.Conclusion:We conclude that the above two NADC30-like strains may have been introduced from North America to China, where they acquired new genetic diversity.
Highlights
Porcine reproductive and respiratory syndrome (PRRS) is one of the most important infectious diseases in swine
NADC30-like strains of porcine reproductive and respiratory syndrome virus first appeared in Chinese swine herds in 2012
We conclude that the above two NADC30-like strains may have been introduced from North America to China, where they acquired new genetic diversity
Summary
Porcine reproductive and respiratory syndrome (PRRS) is one of the most important infectious diseases in swine. This disease leads to reproductive failure in sows and respiratory disease in pigs of all ages [1, 2]. PRRSV isolates are always identified in their respective geographic regions, coexistence of the two types has been found in Europe, North America, and Asia. Such coexistence has had a major impact on PRRS diagnosis and management [9 - 11]. NADC30-like strains of porcine reproductive and respiratory syndrome virus first appeared in Chinese swine herds in 2012
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